Search Results - Biotechnology

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Diagnosis of inflammation from H&E staining images
Tissue samples are processed using hematoxylin and eosin (H&E) staining techniques in order to generate histology tissue images for inflammatory disease diagnosis. Conventionally, H&E stained histology tissue images are manually analyzed by a trained pathologist, which can be tedious and time consuming. A computer automated image analysis...
Published: 6/12/2017   |   Inventor(s): Danny Chen, Rageshree (Raga) Ramachandran, John MacKenzie, Jiazhuo Wang
Category(s): Computer Science & Communication, Biotechnology, Medical Diagnostics
CMARK: a Matlab Toolbox for Segmentation and Tracking of Cells in Time-lapse Images
How fast does a cell move and which cells are moving together? We can help you answer those questions. Tracking the motion of cells and bacteria in time-lapse images is a fundamental step in many biological or clinical research studies. We have developed a complete toolkit for producing quantitative cell dynamics analysis. It includes automatic...
Published: 5/4/2017   |   Inventor(s): Jianxu Chen, Mark Alber, Danny Chen
Category(s): Biotechnology, Computer Science & Communication
Microbiome Characterization with CZE
Microbes often grow in complex communities, called microbiomes. Communal properties such as robustness and division of labor are among the benefits to the organisms within a microbiome. Their interactions have been known to promote survival in otherwise unfavorable environments, but present obstacles to researchers across several fields. The greate...
Published: 11/1/2016   |   Inventor(s): Bonnie Huge, Norman Dovichi, Matthew Champion
Category(s): Biotechnology, Environmental Technology, Medical Diagnostics
Capillary electrophoresis instrumentation and method for forensic analysis of sexual assault evidence
In order to address the national backlog in processing sexual assault kits, a purified sample of male DNA must be selectively retrieved from a gynecological swab. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial cells and other debris allow for a successful polymerase chain reaction (PCR) ...
Published: 8/26/2016   |   Inventor(s): Norman Dovichi, Sarah Lum, Bonnie Huge, Carlos Gartner
Category(s): Biotechnology, Devices
A Genetic Engineering Method for the Production of Peptide Therapeutics
Novel peptide therapeutics which specifically target to and kill certain types of cancer cells are provided. Also an overall method for the synthesis of small, bioactive peptide therapeutics is developed using a primer-based gene synthesis approach coupled with E. Coli-based heterologous protein expression and purification. The genetic engineering...
Published: 5/27/2015   |   Inventor(s): Shaun Lee, Clayton Thomas, Daniel Alber
Category(s): Biotechnology, Medical Diagnostics
Design, Synthesis and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A
Specific interactions of cells within the extracellular matrix are critical for the normal function of organisms. The alterations are carried out in various cellular processes such as organ development, ovulation, fetus implantation in the uterus, embryogenesis, would healing and angiogenesis. Inhibition of the MMPs can be useful in the treatment...
Published: 5/27/2015   |   Inventor(s): Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Shahriar Mobashery
Category(s): Therapeutic, Biotechnology
Matrix Metalloproteinases in Wound Healing
A complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inh...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery
Category(s): Biotechnology, Therapeutic
An Essential Molecule for Long-term Maintenance of Drosophila Cells in a Chemically-defined Medium
A chemically defined medium for both Cl.8 cells and the industrially relevant cell line Drosophila S2 that has long-term potential to maintain cell viability and growth over multiple passages. These new media “ZB” were compared to a known ZO medium. C1.8 cells were seeded at high confluency in unfortified ZO medium and ZB-fortified medi...
Published: 4/1/2014   |   Inventor(s): Jeremiah Zartman, Miranda Burnette, Teresa Brito-Robinson
Category(s): Therapeutic, Biotechnology
Surface Enhanced Raman Flow Detector
urface Enhanced Raman Scattering is used to extract the chemical identify of analytes for positive identification of compounds. By coupling a sheath flow upstream of a SERS detection field we have increased the sensitivity of the system and shown it is useful in the detection of minute amounts of biological molecules such as metabolic intermediari...
Published: 4/1/2014   |   Inventor(s): Zachary Schultz, Oluwatosin (Tosin) Dada, Pierre Negri, Kevin Jacobs
Category(s): Medical Diagnostics, Biotechnology, Microfluidics
Affinity-based Precipitation for Non-chromatographic Purification of Bivalently Active Antibodies
An affinity-based precipitation method for the rapid and nonchromatographic purification of bivalently active monoclonal antibodies combines the selectivity of affinity chromatography with the simplicity of salt-induced precipitation. The process demonstrates the abililty to purify antibodies from typical contaminants including CHO cell conditione...
Published: 1/20/2014   |   Inventor(s): Zihni (Basar) Bilgicer, Michael Handlogten, Jared Stefanick, Nathan Alves, Tanyel Kiziltepe-Bilgicer
Category(s): Biotechnology, Medical Diagnostics, Therapeutic
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