Search Results - Biotechnology

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Diagnosis of inflammation from H&E staining images
Tissue samples are processed using hematoxylin and eosin (H&E) staining techniques in order to generate histology tissue images for inflammatory disease diagnosis. Conventionally, H&E stained histology tissue images are manually analyzed by a trained pathologist, which can be tedious and time consuming. A computer automated image analysis...
Published: 6/12/2017   |   Inventor(s): Danny Chen, Rageshree (raga) Ramachandran, John Mackenzie, Jiazhuo Wang
Category(s): Computer Science & Communication, Biotechnology, Medical Diagnostics
CMARK: a Matlab Toolbox for Segmentation and Tracking of Cells in Time-lapse Images
How fast does a cell move and which cells are moving together? We can help you answer those questions. Tracking the motion of cells and bacteria in time-lapse images is a fundamental step in many biological or clinical research studies. We have developed a complete toolkit for producing quantitative cell dynamics analysis. It includes automatic...
Published: 5/4/2017   |   Inventor(s): Jianxu Chen, Mark Alber, Danny Chen
Category(s): Biotechnology, Computer Science & Communication
Microbiome Characterization with CZE
Microbes often grow in complex communities, called microbiomes. Communal properties such as robustness and division of labor are among the benefits to the organisms within a microbiome. Their interactions have been known to promote survival in otherwise unfavorable environments, but present obstacles to researchers across several fields. The greate...
Published: 11/1/2016   |   Inventor(s): Bonnie Huge, Norman Dovichi, Matthew Champion
Category(s): Biotechnology, Environmental Technology, Medical Diagnostics
Capillary electrophoresis instrumentation and method for forensic analysis of sexual assault evidence
In order to address the national backlog in processing sexual assault kits, a purified sample of male DNA must be selectively retrieved from a gynecological swab. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial cells and other debris allow for a successful polymerase chain reaction (PCR) ...
Published: 8/26/2016   |   Inventor(s): Norman Dovichi, Sarah Lum, Bonnie Huge, Carlos Gartner
Category(s): Biotechnology, Devices
Design, Synthesis and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A
Specific interactions of cells within the extracellular matrix are critical for the normal function of organisms. The alterations are carried out in various cellular processes such as organ development, ovulation, fetus implantation in the uterus, embryogenesis, would healing and angiogenesis. Inhibition of the MMPs can be useful in the treatment...
Published: 5/27/2015   |   Inventor(s): Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Shahriar Mobashery
Category(s): Therapeutic, Biotechnology
An Essential Molecule for Long-term Maintenance of Drosophila Cells in a Chemically-defined Medium
A chemically defined medium for both Cl.8 cells and the industrially relevant cell line Drosophila S2 that has long-term potential to maintain cell viability and growth over multiple passages. These new media “ZB” were compared to a known ZO medium. C1.8 cells were seeded at high confluency in unfortified ZO medium and ZB-fortified medi...
Published: 4/1/2014   |   Inventor(s): Jeremiah Zartman, Miranda Burnette, Teresa Brito-robinson
Category(s): Therapeutic, Biotechnology
Surface Enhanced Raman Flow Detector
urface Enhanced Raman Scattering is used to extract the chemical identify of analytes for positive identification of compounds. By coupling a sheath flow upstream of a SERS detection field we have increased the sensitivity of the system and shown it is useful in the detection of minute amounts of biological molecules such as metabolic intermediari...
Published: 4/1/2014   |   Inventor(s): Zachary Schultz, Oluwatosin (tosin) Dada, Pierre Negri, Kevin Jacobs
Category(s): Medical Diagnostics, Biotechnology, Microfluidics
Conjugation of Multiple Growth Factors to Hydroxyapatite-Collagen Scaffolds for Improved Bone Regeneration via Sequential, Sustained Delivery
The technology augments synthetic bone graft substitutes by recruiting native cells and growth factors to aid in healing processes (i.e. bone regeneration in large defects). The technology deploys sequential and sustained release of multiple growth factors using separate covalent and non-covalent conjugation mechanisms to Hydroxyapatite and collag...
Published: 1/20/2014   |   Inventor(s): Ryan Roeder, Matthew Meagher, Robert Kane
Category(s): Advanced Materials, Biotechnology, Devices, Engineering, Therapeutic
Selective UV Crosslinking of Peptides and Functional Moieties to Antibodies
A method for covalently attaching peptides and small molecules to antibodies through a highly conserved binding domain located on the antibody Fab fragment. This conserved domain has been observed across all species and all immunoglobulin isotypes an provides for an excellent insertion location for near limitless possible functional moieties. Thr...
Published: 1/20/2014   |   Inventor(s): Zihni (basar) Bilgicer, Nathan Alves
Category(s): Biotechnology, Medical Diagnostics, Therapeutic
Antibody Purification Via Affinity Chromatography that Utilizes the Nucleotide Binding Site
Novel affinity chromatography method that utilizes the Nucleotide Binding Site (NBS) as a target for selectively purifying antibodies from complex mixtures. Antibodies can be selectively captured and retained on a NBS IBA column and can successfully eluted by applying a mild NaCl gradient. The NBS IBA column consistently yields >95% antibody r...
Published: 1/20/2014   |   Inventor(s): Zihni (basar) Bilgicer, Tanyel Kiziltepe bilgicer, Michael Handlogten, Nathan Alves, Jonathan Ashley
Category(s): Biotechnology, Medical Diagnostics, Therapeutic
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