Search Results - Life sciences

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Factor XII Deficient Mice
A genetically-transmissible factor (F) XII-inactiviated allele has been produced in mice by targeted replacement of exons 3-8 of the FXII gene with the neomycin resistance gene. Interbreeding of these mice provided offspring homozygous for two inactivated FXII alleles (FXII-/-). Male and female FXII-deficient mice bred normally in all genotypic c...
Published: 6/7/2018   |   Inventor(s): Francis Castellino
Keywords(s):  
Category(s): Life sciences
Anti-HIV Group 1 introns and a method for curing HIV infection of humans
Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using standard myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and whe...
Published: 9/8/2017   |   Inventor(s): Malcolm Fraser
Keywords(s):  
Category(s): Life sciences
Diagnosis of inflammation from H&E staining images
Tissue samples are processed using hematoxylin and eosin (H&E) staining techniques in order to generate histology tissue images for inflammatory disease diagnosis. Conventionally, H&E stained histology tissue images are manually analyzed by a trained pathologist, which can be tedious and time consuming. A computer automated image analysis...
Published: 6/12/2017   |   Inventor(s): Danny Chen, Rageshree (raga) Ramachandran, John Mackenzie, Jiazhuo Wang
Keywords(s):  
Category(s): Life sciences
CMARK: a Matlab Toolbox for Segmentation and Tracking of Cells in Time-lapse Images
How fast does a cell move and which cells are moving together? We can help you answer those questions. Tracking the motion of cells and bacteria in time-lapse images is a fundamental step in many biological or clinical research studies. We have developed a complete toolkit for producing quantitative cell dynamics analysis. It includes automatic...
Published: 5/4/2017   |   Inventor(s): Jianxu Chen, Mark Alber, Danny Chen
Keywords(s):  
Category(s): Life sciences
Microbiome Characterization with CZE
Microbes often grow in complex communities, called microbiomes. Communal properties such as robustness and division of labor are among the benefits to the organisms within a microbiome. Their interactions have been known to promote survival in otherwise unfavorable environments, but present obstacles to researchers across several fields. The greate...
Published: 11/1/2016   |   Inventor(s): Bonnie Huge, Norman Dovichi, Matthew Champion
Keywords(s):  
Category(s): Life sciences
Iris Recognition Based on Human Interpretable Features
The iris is a stable biometric trait that has been widely used in various security and identification applications. This software code develops iris features for use in forensic and law enforcement applications where positive identification requires a human-in-the-loop solution. Iris features (i.e., crypts) are extracted and presented to the user...
Published: 8/26/2016   |   Inventor(s): Jianxu Chen, Feng Shen, Danny Chen, Patrick Flynn
Keywords(s):  
Category(s): Artificial intelligence and machine learning, Life sciences
System and Method for Image Resolution in Multiphoton Microscopy
Ever wonder why images of living cells and viruses are fuzzy? The Raleigh, or Abbe, limit establishes that one cannot resolve two objects within a half a wavelength of the impinging signal. This makes it particularly difficult to image living cells. That is, until a new discovery was made.In 2014, the Nobel Prize in Chemistry was awarded to Erik Be...
Published: 2/25/2016   |   Inventor(s): Scott Howard, Genevieve Vigil, Yide Zhang
Keywords(s):  
Category(s): Life sciences
Non-Aqueous Electrophoretic Separation System for Bioanalysis and Pharaceutical Screening
This is a point-of-care separation system capable of in-vivo analysis of biomolecular samples. The microfluidic platform utilizes a completely non-aqueous separation solvent, enabling the label-free detection of biomarkers. Coupled with microdialysis sampling upstream, and portable mass spectrometry downstream, this device can be used to provide ...
Published: 5/27/2015   |   Inventor(s): Paul Bohn, Larry Gibson
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Category(s): Life sciences, Healthtech
Design, Synthesis and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A
Specific interactions of cells within the extracellular matrix are critical for the normal function of organisms. The alterations are carried out in various cellular processes such as organ development, ovulation, fetus implantation in the uterus, embryogenesis, would healing and angiogenesis. Inhibition of the MMPs can be useful in the treatment...
Published: 5/27/2015   |   Inventor(s): Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Shahriar Mobashery
Keywords(s):  
Category(s): Life sciences
Matrix Metalloproteinases in Wound Healing
A complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inh...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery
Keywords(s):  
Category(s): Life sciences
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