Search Results - Therapeutic

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Anti-HIV Group 1 introns and a method for curing HIV infection of humans
Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using standard myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and whe...
Published: 9/8/2017   |   Inventor(s): Malcolm Fraser
Keywords(s):  
Category(s): Therapeutic
Non-beta lactam antibiotics (oxadiazoles)
The newly discovered oxadiazole class of antibiotics impairs cell-wall biosynthesis and exhibits activities against the Gram-positive bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. They are efficacious in a mouse model of MRSA infection, exhibiting a lon...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery, Edward Spink, Derong Ding, Sebastian Testero, Erika Leemans, Marc Boudreau
Keywords(s):  
Category(s): Therapeutic
Treatment for Diabetic Chronic Wounds
Matrix metalloproteinase (MMPs) is responsible for the turnover and degradation of the extracellular matrix, including collagen. We have evidence that certain selective MMP inhibitors are effective in the treatment of chronic wounds. We have evaluated three such inhibitors in a mouse model of diabetic wounds and have shown that the compounds are ...
Published: 5/27/2015   |   Inventor(s): Shahriar Mobashery, Mark Suckow, Mayland Chang, Mijoon Lee
Keywords(s):  
Category(s): Therapeutic
Gelatinase Inhibitors and Prodrugs
Compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinase (MMPs) can be useful in the treatment of stroke and neurological disorders . Providing a prodrug compound that metabolizes to an active MMP inhibitor in vivo. MMP inhibition can be selective, thus non-mutagen...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery, Mijoon Lee
Keywords(s):  
Category(s): Therapeutic
MMPs that cross the blood-brain barrier
Matrix metalloproteinase play and important role in the pathology of many neurological diseases. Disclosed as part of this invention are novel small molecule therapeutic candidates which are capable of crossing the blood-brain barrier. These compounds may be effective treatments for chronic wounds, certain forms of cancer, traumatic brain injury,...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery
Keywords(s):  
Category(s): Therapeutic
New Antibiotics of a Novel Class I
Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. Researcher at the University of Notre Dame discovered a new class of non-β-lactam antibiotics, the oxadiazoles, which inhibit penicillin-binding p...
Published: 5/27/2015   |   Inventor(s): Shahriar Mobashery, Dusan Hesek, Mayland Chang
Keywords(s):  
Category(s): Therapeutic
Design, Synthesis and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A
Specific interactions of cells within the extracellular matrix are critical for the normal function of organisms. The alterations are carried out in various cellular processes such as organ development, ovulation, fetus implantation in the uterus, embryogenesis, would healing and angiogenesis. Inhibition of the MMPs can be useful in the treatment...
Published: 5/27/2015   |   Inventor(s): Mijoon Lee, Masahiro Ikejiri, Mayland Chang, Shahriar Mobashery
Keywords(s):  
Category(s): Therapeutic, Biotechnology
Matrix Metalloproteinases in Wound Healing
A complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inh...
Published: 5/27/2015   |   Inventor(s): Mayland Chang, Shahriar Mobashery
Keywords(s):  
Category(s): Biotechnology, Therapeutic
An Essential Molecule for Long-term Maintenance of Drosophila Cells in a Chemically-defined Medium
A chemically defined medium for both Cl.8 cells and the industrially relevant cell line Drosophila S2 that has long-term potential to maintain cell viability and growth over multiple passages. These new media “ZB” were compared to a known ZO medium. C1.8 cells were seeded at high confluency in unfortified ZO medium and ZB-fortified medi...
Published: 4/1/2014   |   Inventor(s): Jeremiah Zartman, Miranda Burnette, Teresa Brito-Robinson
Keywords(s):  
Category(s): Therapeutic, Biotechnology
Affinity-based Precipitation for Non-chromatographic Purification of Bivalently Active Antibodies
An affinity-based precipitation method for the rapid and nonchromatographic purification of bivalently active monoclonal antibodies combines the selectivity of affinity chromatography with the simplicity of salt-induced precipitation. The process demonstrates the abililty to purify antibodies from typical contaminants including CHO cell conditione...
Published: 1/20/2014   |   Inventor(s): Zihni (Basar) Bilgicer, Michael Handlogten, Jared Stefanick, Nathan Alves, Tanyel Kiziltepe-Bilgicer
Keywords(s):  
Category(s): Biotechnology, Medical Diagnostics, Therapeutic
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