Phosphorus-Mediated Acyl C-C and C-N Bond Formations

Description:

The technology allows for ready access to a diverse assortment of amides through the direct functionalization of carboxylic acids and azides by using a chlorophosphite as a dual activating agent, and results in simplified product isolation due to the aqueous solubility of the byproducts generated.

The bimodal reactivity of phosphite to unmask the latent electrophilicity of carboxylic acids and is directly applicable to the assembly of biologically active natural products and synthetic targets containing amides, lactams, and peptide linkages.

 

ADVANTAGES INCLUDE:

 - Ability to conduct the acyl substitution of carboxylic acids directly without product-isolation complications common to conventional dehydration methods.

Patent Information:
Category(s):
Chemical
Therapeutic
For Information, Contact:
Karen Deak
Director
University of Notre Dame
574 631-6695
kdeak@nd.edu
Inventors:
Brandon Ashfeld
Erin Wilson
Keywords:
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