Capillary electrophoresis instrumentation and method for forensic analysis of sexual assault evidence


In order to address the national backlog in processing sexual assault kits, a purified sample of male DNA must be selectively retrieved from a gynecological swab. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial cells and other debris allow for a successful polymerase chain reaction (PCR) amplification and short tandem repeat (STR) analysis of the perpetrator DNA. An improved method to perform the cell separation boasts three major advantages over present technologies: small sample size allowing for multiple analysis of limited available evidence, rapid separation time compared to standard methods and single cell detection and collection. In this invention, sperm migrate in a confined band in less than 30 minutes. The sample is collected into individual wells on a well-plate. The isolated sample will then undergo PCR amplification and STR analysis for forensic identification.

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For Information, Contact:
Michelle Wheeler
Commercial Program Manager
University of Notre Dame
Norman Dovichi
Sarah Lum
Bonnie Huge
Carlos Gartner
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