Latest technologies from University of Notre Damehttp://notredametech.technologypublisher.comBe the first to know about the latest inventions and technologies available from University of Notre Dameen-USWed, 23 May 2018 13:26:05 GMTFri, 08 Sep 2017 11:06:49 GMT 2018, University of Notre DameAnti-HIV Group 1 introns and a method for curing HIV infection of humans, 08 Sep 2017 11:06:49 GMTott@nd.edu<![CDATA[Diagnosis of inflammation from H&E staining images]]>, 12 Jun 2017 19:13:36 GMTott@nd.edu Electrode-Enabled Dual-Cell Detectors for Electrochromic Sensing, 12 Jun 2017 18:50:26 GMTott@nd.edu a Matlab Toolbox for Segmentation and Tracking of Cells in Time-lapse Images, 04 May 2017 07:31:27 GMTott@nd.edu charge solid state Li-ion batteries, 06 Nov 2016 12:30:50 GMTott@nd.edu and Manufacturing of a Solid State Battery, 06 Nov 2016 12:30:06 GMTott@nd.edu Characterization with CZE often grow in complex communities, called microbiomes. Communal properties such as robustness and division of labor are among the benefits to the organisms within a microbiome. Their interactions have been known to promote survival in otherwise unfavorable environments, but present obstacles to researchers across several fields. The greatest obstacles are identification of individual organisms and their specific contribution to the microbiome. Researchers at the University of Notre Dame have made an automated device to separate and concentrate bacterial cells for analysis.Tue, 01 Nov 2016 09:05:23 GMTott@nd.edu End-to-End Path Characterization involving Wireless Network Hops, 19 Oct 2016 11:30:13 GMTott@nd.edu of Glial Cells in 3D Microscopy Images cells play an important role in regulating synaptogenesis, development of blood-brain barrier, and brain tumor metastasis. Quantitative analysis of glial cells can offer new insights to many studies. However, the complicated morphology of the protrusions of glial cells and the entangled cell-to-cell network cause significant difficulties to the extraction of quantitative information in images. This disclosure presents a new method for instance-level segmentation of glial cells in 3D microscopy images. First, the new method obtains accurate voxel-level segmentation by leveraging the recen...Fri, 07 Oct 2016 06:18:50 GMTott@nd.edu of self-assembly for inorganic nanowires in solution into films and yarns, 07 Oct 2016 06:16:39 GMTott@nd.edu Technique for Client-Side Passive Detection of WiFi Access Point Load (c) 2016, 28 Sep 2016 06:55:35 GMTott@nd.edu Mechanism for Conveying Residual Capacity at a Wireless Access Point, 28 Sep 2016 06:54:38 GMTott@nd.edu Recognition Based on Human Interpretable Features, 26 Aug 2016 12:50:34 GMTott@nd.edu electrophoresis instrumentation and method for forensic analysis of sexual assault evidence order to address the national backlog in processing sexual assault kits, a purified sample of male DNA must be selectively retrieved from a gynecological swab. Effective elution of the sample from the swab and efficient separation of intact sperm cells from epithelial cells and other debris allow for a successful polymerase chain reaction (PCR) amplification and short tandem repeat (STR) analysis of the perpetrator DNA. An improved method to perform the cell separation boasts three major advantages over present technologies: small sample size allowing for multiple analysis of limited availa...Fri, 26 Aug 2016 08:02:39 GMTott@nd.edu Transmission for Analog RF Isolation, 24 Aug 2016 14:30:25 GMTott@nd.edu Fabric functionalization of fibers and fabrics using solution-synthesized quantum nanowires may be possible with this invention. Conformal coatings onto individual fibers can be achieved through certain physical and chemical approaches. Resulting nanowire-functionalized textiles consist of dense, conformal coatings and can be characterized for their UV-visible absorption as well as Raman activity. Potential applications include barcoding fibrous products and fiber-based photodetectors. Future applications may include medical, anti-counterfeiting and photocatalytic applications.Thu, 28 Jul 2016 14:31:42 GMTott@nd.edu Field Effect Transistor (TFET)-based Well Capacity Adjustment in Active Pixel Sensor (APS) for Enhanced High Dynamic Range (HDR) conduction of emerging transistors is employed to circumvent the sub-threshold operation of the reset transistor in active pixel sensors where dynamic well capacity adjustment is applied to extend the dynamic range. In current CMOS technology, this sub-threshold operation adds spatial-temporal noise on the pixel signal and gives rise to large dips in the signal-to-noise ratio. Novel transistor designs remove these undesired effects while keeping the crucial advantages of dynamic well capacity adjustment, i.e. large increase in dynamic range, simple operation, high performance unde...Thu, 23 Jun 2016 12:45:12 GMTott@nd.edu and Method for Image Resolution in Multiphoton Microscopy, 25 Feb 2016 09:30:48 GMTott@nd.edu Active Layered Double Hydroxide-Derived Cobalt Nano-Catalysts for Catalytic Water Treatment parity condition, that the reactivity ration between non-precious and precious metal catalysts must exceed their price ration, has been surpassed for cobalt, in comparison to the most active precious metal catalyst made of palladium, in the catalytic reduction of p-nitrophenol with borohydride. This is achieved by affixing CO nanoparticles on two-dimensional layered double oxide nanodisks through thermal phase transformation of cobalt-magnesium-aluminum layered double hydroxide precursors. Compared to other CO nano-catalysts in the literature, the layered double oxide-Co catalyst has incre...Fri, 16 Oct 2015 06:34:21 GMTott@nd.edu Heart Monitor Monitor:Researchers at the University of Notre Dame were collecting data in an experiment using remote sensing to find contaminants in food products when they noticed sensitivities to the slightest movement or position changes within the lab room. They speculated that the experimenters' chest motions and even internal organ shape changes, like a heart beating, could influence their measured responses. By redesigning their system they were able to create a remote sensing device that could measure responses due, not to a heart's electrical signals, but to its actual physical movements. Thi...Thu, 24 Sep 2015 14:23:33 GMTott@nd.edu Nanomagnet Logic logic (NML), a nonvolatile digital computational method based on nanoscale magnetic structures, takes a leap forward with innovation from researchers at Notre Dame. Now, with the newly developed Synchronous NML (SNML) method, data may be reliably clocked into logic circuits without the common and troublesome stochastic switching that can cause adjacent cells to miss-record data in conventional NML. The novel SNML design eliminates errors in NML while at the same time increasing throughput by allowing higher data speed and pipelined rates. In the new SNML embodiment, it is now feasib...Wed, 17 Jun 2015 09:23:09 GMTott@nd.edu Electrophoretic Separation System for Bioanalysis and Pharaceutical Screening, 27 May 2015 07:36:04 GMTott@nd.edu Genetic Engineering Method for the Production of Peptide Therapeutics, 27 May 2015 07:33:49 GMTott@nd.edu lactam antibiotics (oxadiazoles), 27 May 2015 07:32:01 GMTott@nd.edu for Diabetic Chronic Wounds, 27 May 2015 07:30:20 GMTott@nd.edu Inhibitors and Prodrugs, 27 May 2015 07:29:16 GMTott@nd.edu that cross the blood-brain barrier, 27 May 2015 07:27:28 GMTott@nd.edu Antibiotics of a Novel Class I, 27 May 2015 07:26:29 GMTott@nd.edu, Synthesis and Evaluation of a Mechanism-Based Inhibitor for Gelatinase A, 27 May 2015 07:12:06 GMTott@nd.edu Metalloproteinases in Wound Healing complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inhibitor-tethered resin that binds exclusively to the active forms of MMPs, coupled with proteomics, we quantified MMP-8 and MMP-9 in a mouse model of diabetic wounds. Topical treatment with a selective MMP-9 inhibitor led to acceleration of wound heal...Wed, 27 May 2015 07:11:07 GMTott@nd.edu Released from Mycobacterium Tuberculosis-Infected Cells as Diagnostic Markers of Disease, 27 May 2015 07:06:48 GMTott@nd.edu E as a Marker of Colon Cancer, 27 May 2015 07:03:06 GMTott@nd.edu Performance Near Infrared Photothermal Dyes, 27 May 2015 07:00:51 GMTott@nd.edu Nanoscale Thermocouples, 01 May 2015 05:56:30 GMTott@nd.edu Sensor and Probe, 13 Mar 2015 10:17:08 GMTott@nd.edu Plasma Anemometer for Hypersonic Mach Number Experiments, 12 Mar 2015 07:58:59 GMTott@nd.edu DC Pump/Electrospray Formulation and aeration of nanodroplets for use in analytical instrumentation and drug deliveryThu, 12 Mar 2015 07:19:02 GMTott@nd.edu and Apparatus for AC Electrospray, 10 Mar 2015 14:44:48 GMTott@nd.edu of Gas with Liquid Ionic Compounds, 10 Mar 2015 14:10:05 GMTott@nd.edu Cartridge for Hydrogen Production Production of hydrogen gas in a fuel cell environment through copper based catalysts combined with noble metals.Mon, 02 Mar 2015 11:08:59 GMTott@nd.edu Metrics, Sampling Schemes, and Detection Algorithms for Wideband Spectrum Sensing, 07 Jan 2015 12:56:28 GMTott@nd.edu Essential Molecule for Long-term Maintenance of Drosophila Cells in a Chemically-defined Medium, 01 Apr 2014 11:49:34 GMTott@nd.edu Up-conversion Using Core-shell Nanostructures upconverting nanostructures (CSUNs) increase the efficiency of multijunction photovoltaic cells by utilizing low-energy photons, rearranging the spectral distribution between cell layers, compensating for strain, and utilizing large band-gap materials which provide lower photon loss.Tue, 01 Apr 2014 11:49:33 GMTott@nd.edu Analytical Device for Quantifying Iodine in Fortified Salt A paper analytical device (PAD) for use in low-resource settings to test for the presence of iodine in salt. To test the salt, a solution of the salt and water is dropped onto the PAD in several reaction zones. The pad is quantitative in the range of 0.95-15 ppm iodine with a precision of 0.5 ppm iodine (as mg iodine per kg salt). The PAD may be interfaced with cell phone camera technology to allow refined quantification by colorimetry.Tue, 01 Apr 2014 11:49:32 GMTott@nd.edu Enhanced Raman Flow Detector, 01 Apr 2014 11:49:28 GMTott@nd.edu Based Tuning Fork Holder, 19 Feb 2014 09:37:42 GMTott@nd.edu Precipitation for Non-chromatographic Purification of Bivalently Active Antibodies, 20 Jan 2014 10:55:15 GMTott@nd.edu Liposome Purification via Liposome Extruder Purification (LEP), 20 Jan 2014 10:55:13 GMTott@nd.edu of Multiple Growth Factors to Hydroxyapatite-Collagen Scaffolds for Improved Bone Regeneration via Sequential, Sustained Delivery, 20 Jan 2014 10:55:07 GMTott@nd.edu UV Crosslinking of Peptides and Functional Moieties to Antibodies, 20 Jan 2014 10:55:03 GMTott@nd.edu Purification Via Affinity Chromatography that Utilizes the Nucleotide Binding Site, 20 Jan 2014 10:54:59 GMTott@nd.edu General-purpose Compiler for Private Distributed Computation This technology details a means of achieving secure computing of sensitive information in a multi-party, shared resource environment. The computing of sensitive information can now be accomplished in a cloud computing framework without risking data security. Applications exist in the health, financial, and other information-sensitive markets or when sensitive data is shared between separate organizations. The private distributed computation compiler (PICCO) is a source-to-source complier that works on any platform and translates a program written in an extension of the C programming language ...Tue, 26 Nov 2013 12:22:13 GMTott@nd.edu Acyl C-C and C-N Bond Formations, 26 Nov 2013 12:22:10 GMTott@nd.edu method for the preparation of metals supported on carbon, 10 Oct 2013 12:38:53 GMTott@nd.edu Vertical Power Transistor Device, 20 Aug 2013 08:26:33 GMTott@nd.edu Robots for Improving Medical Education, 20 Aug 2013 08:26:20 GMTott@nd.edu and characterization of a beneficial bacterium inside the seed of mung bean (Vigna radiata), 26 Jun 2013 09:17:57 GMTott@nd.edu Molecule Sensing by Dynamic Assembly of Nanoparitcles in Conic Nanopores (DANCON), 24 May 2013 10:34:47 GMTott@nd.edu, Modular, Rapidly Deployable Shelter, 24 May 2013 10:34:45 GMTott@nd.edu Wellness: A Data-Driven Approach, 04 Apr 2013 15:27:24 GMTott@nd.edu driven mapping of 2D images to 3D surfaces, 04 Apr 2013 15:27:19 GMTott@nd.edu XII Deficient Mice, 15 Mar 2013 06:37:01 GMTott@nd.edu New Class of Quinazolinone Antibiotics, 15 Mar 2013 06:37:00 GMTott@nd.edu Artificial Pinning Array for Enhanced Pinning of Superconducting Vortices, 15 Mar 2013 06:36:59 GMTott@nd.edu Coke Reduction of Biomass using Cerium-Containing Zeolites, 15 Mar 2013 06:36:18 GMTott@nd.edu Filtration Membranes Derived from Self-assembled Multiblock Polymers, 28 Nov 2012 10:07:15 GMTott@nd.edu Branched Polymers with Uniform Structure in Confined Space, 28 Nov 2012 10:07:11 GMTott@nd.edu of Producing Graphene and Other Carbon Materials, 28 Nov 2012 10:07:10 GMTott@nd.edu production platforms for the production of gephyronic acid and related polyketides., 28 Nov 2012 10:07:08 GMTott@nd.edu Enhanced Raman Substrate by Thermal Evaporation of Metal in Porous Filter Template, 28 Nov 2012 10:07:05 GMTott@nd.edu Body Nitride-on-Insulator Quantum Well Field Effect Transistors, 28 Nov 2012 10:07:02 GMTott@nd.edu Scale: A Design and Analysis Tool for Sustainable Buildings, 28 Nov 2012 10:07:01 GMTott@nd.edu Driven Engineering of Multifunctional Nanoparticles and Method of Use, 28 Nov 2012 10:06:55 GMTott@nd.edu Wave Amplitude Modulator, 28 Nov 2012 10:06:53 GMTott@nd.edu Solution-phase Synthesis of TiS2 Nanobelts Layered titanium dichalcogenides (i.e. TiX2 where X=S, Se, Te) are representative members of an extended family of two-dimensional (2D) metal dichalcogenides that exhibit anisotropic physical properties. These anisotropies arise from strong, covalent M—X intralayer bonding motifs in contrast to the weak van der Waals bonding between layers. Both the layered structure and the anisotropy of interatomic bonds make it possible to create different low dimensional systems (such as, fullerene-like nanoparticles, nanotubes, nanodisks, nanobelts etc...) as well as intercalation and ...Wed, 28 Nov 2012 10:06:52 GMTott@nd.edu Carbon Nanotube Filters for Oil-Water Separation technology for the separation of oil in water using a nanostructured platform.Wed, 28 Nov 2012 10:06:48 GMTott@nd.edu for Lipid Trafficking, 28 Nov 2012 10:06:46 GMTott@nd.edu and Apparatus for RF Sensing, 28 Nov 2012 10:06:38 GMTott@nd.edu pH and pH gradient control for rapid isoelectric separation and other applications, 28 Nov 2012 10:06:35 GMTott@nd.edu, Label-Free and High-Throughput Electrokinetic Membrane Biosensors with Surface-Charge Inversion Signature, Buffer Composition Control and Micro-Circulation Sensitivity Enhancement A rapid and label-free biosensor for the detection of DNA, RNA and other molecular biomarkers at high throughput. This technology is based on how molecular docking can affect surface charge on a membrane and alter both local hydrodynamics and ion transport. This affect is can be measured sensitively and accurately. Wed, 28 Nov 2012 10:06:33 GMTott@nd.edu Antifreeze Glycolipids Antifreeze glycoproteins that have been isolated from a freeze tolerant organisms. This glycoprotein can possibly be used for inproved cryopreservation of biologically and medically important materials for research, organ and tissue transplant, and other purposes.Wed, 28 Nov 2012 10:06:29 GMTott@nd.edu Coexpression hub genes predict relapse in estrogen receptor positive breast cancer Patterns of gene expression were analyzed to measure the aggressiveness of a breast cancer tumor. A formula based on this analysis produces a score that predicts the recurrence rate of breast cancerWed, 28 Nov 2012 10:06:25 GMTott@nd.edu Line Gather/Scatter Intra-Cache Line Gather/Scatter (ICLGS) aggregates multiple loads (or multiple stores) from a single "cache line" into a single instruction speeding a micropressor invoking a decomplier instruction processWed, 28 Nov 2012 10:06:24 GMTott@nd.edu and Robust Crystallization of Proteins and other Biomolecules Using an AC Electric Field By applying the correct frequency and voltage, the AC field breaks the hydration cage surrounding the proteins. This technique has shown to produce high quality crystals.Wed, 28 Nov 2012 10:06:22 GMTott@nd.edu Transposition Demonstrates Piggybac Mobility in Vertebrate Species Extremely versatile helper-dependent vector for gene transfer and germ line transformation in a wide range of eukaryotic species. Analyses of genome sequencing databases have identified piggyBac homologues among several sequenced animal genomes. This insect transposon is capable of transposition in primate cells.Wed, 28 Nov 2012 10:06:08 GMTott@nd.edu Hardware for Radiation Dose Calculation Utilizing this technology, more intricate and specific geometries can be quickly and effectively targeted during tumor cancer therapiesWed, 28 Nov 2012 10:06:06 GMTott@nd.edu InAlP as Host for Optically-Active Er Improved waveguide and amplifier performance in optoelectronic devices, i.e. lasers.Wed, 28 Nov 2012 10:06:02 GMTott@nd.edu Trap (Method for Non-Contact Microfluidic Sample Manipulation) Microfluidic sample preparation tool that make use of electrokinetics. More specifically, this technology manipulates a liquid sample on the nanoscale through the use of AC electric fields by inducing an ionic wind to separate and concentrate particles in a sample.Wed, 28 Nov 2012 10:06:00 GMTott@nd.edu Cartridge for Hydrogen Production Production of hydrogen gas in a fuel cell environment through copper based catalysts combined with noble metals.Wed, 28 Nov 2012 10:05:57 GMTott@nd.edu DC Pump/Electrospray Formulation and aeration of nanodroplets for use in analytical instrumentation and drug deliveryWed, 28 Nov 2012 10:05:54 GMTott@nd.edu Plasma Anemometer for Hypersonic Mach Number Experiments Method and system for obtaining flow information, especially useful for high Mach number situations.Wed, 28 Nov 2012 10:05:49 GMTott@nd.edu Sensor and Probe With a single non-intrusive instrument, wavefront derivatives and wavefront convective velocities can be measured directly; and these can be combined to yield Optical Path Difference (OPD) as a function of time.Wed, 28 Nov 2012 10:05:46 GMTott@nd.edu and Apparatus for AC Electrospray, 28 Nov 2012 10:05:37 GMTott@nd.edu of Gas with Liquid Ionic Compounds, 28 Nov 2012 10:05:24 GMTott@nd.edu Test for Relapse in Estrogen-receptor positive breast cancer using the expression status of few genes Novel accelerated progression relapse test can separate patients with good prognosis from those with bad prognosis using an assay of four identified genes at a fraction of the cost of other methods. Many breast cancer patienst will remain relapse-free even without chemotherapy, however, accepted clinico-pathological variables are unreliable indicators of prognosis. The novel accelerated progression relapse test separates patient with good prognosis from those with a poor prognosis using a simpe assay of four genes. It offers a test for relapse with power comparable to others on the mar...Wed, 28 Nov 2012 10:05:02 GMTott@nd.edu Antibiotics of a Novel Class-II Novel antibacterials that target penicillin-binding proteins and/or other important cellular targets in order to inhibit growth of bacteria such as Entercoccus and Staphylococcus aureus.Wed, 28 Nov 2012 10:05:00 GMTott@nd.edu Detection in Dynamic Spectrum Access Networks, 28 Nov 2012 10:04:55 GMTott@nd.edu Catalyst for Diesel Particulate Filters Novel material lowers the catalysis temperature for carbon soot. Improves engine performance and eases design restrictionsWed, 28 Nov 2012 10:04:45 GMTott@nd.edu and Release of Viruses through Amino-Functionalized Silica Particles, 28 Nov 2012 10:04:43 GMTott@nd.edu Nanoslot DNA Sensor for Quantitative Real-Time PCR, 28 Nov 2012 10:04:42 GMTott@nd.edu Turbine Performance Improvement, Unsteady Load and Acoustic Level Attenuation Using On-Blade Single Dielectric Barrier Discharge (SDBD) Plasma Actuators, 28 Nov 2012 10:04:41 GMTott@nd.edu Tractor and Trailer Aerodynamic Drag Reduction using Single Dielectric Barrier Discharge (SDBD) Plasma Actuators, 28 Nov 2012 10:04:40 GMTott@nd.edu Optics, 28 Nov 2012 10:04:38 GMTott@nd.edu for the Restoration of Reflexive/Behavioral Determinants of Whole Organisms, as a Marker for Recovery from Disease. The restoration of a cumulative score of reflexive/behavioural determinants may be used as an assay to screen small molecules or drugs that minimize or abrogate neuromuscular function.Wed, 28 Nov 2012 10:04:33 GMTott@nd.edu of Surface GM1 location Screen - a marker for rescue of lipid accumulation defect NP-C cells of cell surface glycosphingolipid GM1 as detected by binding to cholera toxin may be used as an assay to screen for drugs capable of overriding the lipid accumulation defect Niemann Pick Type C is a fatal neurodegenerative disorder. Intracellular accumulation of glycosphingolipids and cholesterol is detected systematically and a hallmark of disease. Reduction of intracellular sphingolipid and cholesterol stores and reversion of disease phenotype can be achieved by promoting lipid efflux from cells. The invention is the idea that restoration of cell surface glycosphingolipid ...Wed, 28 Nov 2012 10:04:32 GMTott@nd.edu of Disease State Detection through Protein/Molecular Analysis, 28 Nov 2012 10:04:31 GMTott@nd.edu